Gabrielle Wipper
Biomedical engineering
Hometown: Germantown, Tennessee, United States
Graduation date: Spring 2020
FURI | Spring 2020
Discovering Factors That Drive the Migration of Immune Cells Into Malignant Pleural Mesothelioma Tumors
The goal of this research was to map the network of interactions influencing immune cell migration. A series of filters were applied to a transcriptional regulatory network to prioritize a list of chemokines, cytokines, and immunomodulatory genes associated with increased infiltration of immune cells related to patient survival. The chemokine IL-18 was identified as a factor influencing natural killer cell infiltration into malignant pleural mesothelioma (MPM). Currently experimentally determining if patient-derived MPM cell lines express IL-18, and developing a Boyden chamber assay to determine if IL-18 induces chemotaxis and tissue invasion.
Mentor: Christopher Plaisier
It’s hip to be square.
Students presenting projects at the Fulton Forge Student Research Expo are encouraged to download this personal QR code and include it within your poster. This allows expo attendees to explore more about your project and about you in the future.
Right click the image to save it to your computer.