Carlos Ignacio Castillo Bock
Biomedical engineering
Hometown: Altamira, Tamaulipas, Mexico
Graduation date: Spring 2027
FURI | Spring 2026
Developing Blood Vessel-on-a-Chip Platform for Studying Vascular Mechanobiology
This project aims to develop a physiologically relevant blood vessel-on-a-chip platform to study vascular mechanobiology. Using computational fluid dynamics (CFD), microfluidic devices were designed to produce hemodynamic microenvironments, including defined shear stresses and velocity profiles. While custom devices will be fabricated using soft lithography, commercially available microfluidic chips were used to culture human endothelial cells under defined flow conditions. Using qRT-PCR and immunostaining analyses, endothelial cells exhibited significant changes in gene expression and morphology under flow conditions compared to static culture, supporting the platform’s capacity to recapitulate flow-induced cellular responses.
Mentor: Kuei-Chun "Mark" Wang
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