Emily Mahadevan
Biomedical engineering
Hometown: Tucson, Arizona, United States
Graduation date: Spring 2025
Additional details: Honors student
MORE | Fall 2024
Delivery of Alpha-Ketoglutarate from Hyaluronic Acid Hydrogels for Bone Repair Applications
Currently, autograft and allograft bones are the gold standard for treating bone loss, however, they pose many limitations. Immunomodulatory alpha-ketoglutarate (aKG) has the ability to enhance osteoblasts and inhibit osteoclast activity, benefitting bone repair. By generating polymeric microparticles with aKG (paKG MPs), aKG release can be controlled and sustained over time via microparticle degradation. Maleimide-functionalized hyaluronic acid (MaHA) hydrogels were used as a delivery mechanism for the MPs. MaHA was synthesized and hydrogels underwent compression testing with PaKG addition to ensure crosslinking. The in vitro effects of paKG were also evaluated using human mesenchymal stem cells in osteogenic media.
Mentor: Julianne Holloway
It’s hip to be square.
Students presenting projects at the Fulton Forge Student Research Expo are encouraged to download this personal QR code and include it within your poster. This allows expo attendees to explore more about your project and about you in the future.
Right click the image to save it to your computer.
Sponsored project | Fall 2024
Emily Mahadevan’s MORE project is sponsored by W. L. Gore & Associates.
W. L. Gore & Associates is a uniquely creative, product leadership enterprise that has served a variety of global markets for more than 60 years, and provides innovative solutions that its associates stand behind. Gore established funds to support undergraduate students in the Fulton Undergraduate Research Initiative program and graduate students in the Master’s Opportunity for Research in Engineering program, and values student-driven research and developing relationships with students in the programs.