Mark Anthony Orlando
Biomedical engineering
Hometown: Phoenix, Arizona, United States
Graduation date: Fall 2025
Additional details: Honors student
MORE | Spring 2025
Evaluation of a Novel Small Molecule Drug in Vascular Dysfunction
Atherosclerotic cardiovascular disease (ACVD), characterized by the buildup of plaques within blood vessels, remains the leading cause of morbidity and mortality worldwide. Current treatments manage risk factors but do not directly target vascular dysfunction and halt plaque progression. The Wang laboratory recently established a biomimetic nanoparticle platform, enabling site-specific delivery of therapeutic agents to plaques. This MORE project aims to utilize cellular and molecular biology techniques to assess the pharmacological impact of a novel small molecule drug in suppressing vascular dysfunction associated with ACVD. The findings will lay the groundwork for developing a targeted nanodrug for subsequent animal model testing.
Mentor: Kuei-Chun "Mark" Wang
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