FURI | Fall 2025

Developing and Testing a Clinically Translatable Method to Rapidly Assess Local Cerebral Blood Flow in Real Time

Monitoring cerebral blood flow (CBF) is vital for assessing brain health, as fluctuations can signal conditions like stroke & ischemia. This study develops an electrochemical impedance spectroscopy (EIS)-based method to monitor localized CBF in real time. A three-electrode setup consisting of tungsten working, platinum counter and silver reference was tested on benchtop saline, artificial cerebrospinal fluid and porcine brain models, as well as in-vivo murine models, to correlate impedance changes with microvascular fluctuations. This method offers an alternative to bulky monitoring systems, providing dynamic feedback for invasive neurostimulation procedures like deep brain stimulation (DBS), thus improving overall safety and efficacy.