Mia Nguyen
Biomedical engineering
Hometown: Seattle, Washington, United States
Graduation date: Spring 2025
FURI | Spring 2025
Designing a pegRNA to Examine the Impact of BIN1 Variants in HiPSC-Based Models of Alzheimer’s Disease
Alzheimer’s disease (AD), the most common cause of dementia, was officially listed as the sixth-leading cause of death in the United States, with an estimated 6.9 million Americans age 65 and older having passed away due to the condition. The BIN1 locus contains the second-most significant genetic risk factor for late-onset AD, which has not been studied extensively on human-induced pluripotent stem cell (hiPSC) models. In this study, the use of hiPSC provides a versatile system to study risk modifying BIN1 variants. From this project, designed pegRNA can be used in gene therapy to restore wild-type BIN1 variant rs744373; thus, decreasing the risk of AD.
Mentor: David Brafman
It’s hip to be square.
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