Han Nguyen
Computer science
Hometown: Da Nang, Vietnam
Graduation date: Spring 2025
Additional details: Honors student
FURI | Fall 2024
Efficient Identification of Adaptive Therapy Routines for Cancer using Evolutionary Search
In traditional chemotherapy, large doses of drugs are applied for fixed lengths of time, having the side effect of cells developing drug resistance. Adaptive therapy is an effective alternative that treats for stability by adjusting drugs, doses, and timing to maintain competition between drug-resistant and drug-sensitive cells. However, the sheer number of regimens and the costs of clinical trials make it prohibitively expensive to try every adaptive therapy. In this project, the research team uses genetic algorithms and CancerSim, a 3D tumor simulator, to efficiently explore large spaces of adaptive therapies, identifying promising candidates for further study in clinical trials.
Mentor: Joshua Daymude