Alondra Davila
Biomedical engineering
Hometown: Mesa, Arizona, United States
Graduation date: Spring 2025
Additional details: First-generation college student
FURI | Spring 2025
Characterization of Diclofenac-Loaded Lipid Nanoparticles for Neutrophil Modulation
Traumatic brain injury (TBI) results in acute and chronic neuroinflammation that can lead to long-term disability and even death. Nanoparticles (NPs) are a promising drug delivery system, given their physicochemical properties can be tuned to increase drug circulation time and bioavailability. In this study, drug-loaded lipid nanoparticles will be fabricated and incubated with immune cells to determine their anti-inflammatory effects. Diclofenac, an anti-inflammatory drug, will be utilized to decrease the expression of L-selectin on neutrophils. The results of this study will be used to inform future in vivo experiments focusing on decreasing the inflammatory response in the brain after injury.
Mentor: Sarah Stabenfeldt
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