Isaac Coello Dantus

Mechanical engineering

Hometown: Mexico City, State of Mexico, Mexico

Graduation date: Spring 2024

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FURI | Spring 2024

Deconvolution of the Mechanical Effects in Atomic Force Microscopy Material Characterization of Living Cells

Atomic Force Microscopy (AFM) has been extensively used to determine the mechanical properties of materials ranging from ceramics to soft living tissue. There is an increasing use of AFM for the characterization of biological structures, which have been developed into new diagnostic techniques. However, the effects of cell size, substrate and inclusion presence on AFM measurements have not been exhaustively investigated. This study aims to understand these effects through Finite Element Analysis of a size varying cell resting on a glass substrate. The result is a relationship between the height of the cell and the indentation depth necessary for accurate measurements.


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Additional projects from this student

The proper measurement of a biological tissue’s mechanical properties will improve modern diagnostic technics and prosthetic devices.


  • FURI
  • Fall 2023