FURI | Spring 2026

The Role of Estrogen in the Impairment of Cortical Activity in the Brain Following Migraine

Migraines are two to three times more prevalent in females than in males, but the mechanisms that lead to this significant difference between the sexes is not well understood. While hormones such as estrogen have been implicated in this issue, the underlying processes and neuronal pathways are still unclear. This research project aims to shed new light on the relationship between the specific hormone estrogen and migraine prevalence through the various phases of the menstrual cycle. This research will advance knowledge in the field of neurogenic inflammation (migraines), more generally, and gender physiology in migraines, more specifically.