FURI | Spring 2025

Pre-osseointegrated Implants: In Vitro Osteogenesis from Human Osteoblast Cell Lines on Titanium Root Form Dental Implants

The success of dental implants is often compromised by complications associated with bone grafting, including infection risks and the need for donor sites. This research investigates the in vitro generation of human bone from an osteoblast cell line on titanium root form dental implants. Culturing human osteoblast (HOB) cells on implants under sterile conditions has demonstrated significant cellular activity and mineralization, indicating potential for enhanced implant success. This method of using pre-osseointegrated implants eliminates the need for donor sites and reduces infection risks, contributing to advancements in dental implant technology and improving patient outcomes in osseointegration.