FURI | Spring 2021

Interictal Spike Depolarization in the Neocortex: Relationship to Action Potential Inactivation

Evaluated how local voltage changes due to interictal spikes impact action potential firing using intracellular recordings and the Hodgkin-Huxley model. The Hodgkin-Huxley model showed inactivated action potentials being generated by large depolarizations. The Hodgkin-Huxley model confirmed the effect of large interictal spike depolarizations on action potential firing and inactivation. This supports the hypothesis that interictal spikes may contribute to idiopathic seizure disorder.