GCSP research stipend | Fall 2025

Fabrication of Electrospun Biomaterial Scaffolds for the Development of 3D Tissue Engineered Constructs in a Controllable Bioreactor Processing System

Electrospinning is a fabrication technique for the generation of nanoscale fibers under high-voltage electric fields in the range of 10-30 kV. Bombyx mori-derived sericin nano-scaffolds can support cell growth and regeneration by mimicking cellular matrix environments. Biocompatibility studies allow for the investigation of the interactions between cellular environments and biomaterials for the development of bioactive systems and therapies in wound healing and orthopedic fixation applications. This research effort is aimed at developing DOE-derived processing conditions for electrospinning sericin nano-scaffolds for use in a self-sustaining bioreactor system capable of providing continuous maintenance of the bioreactor cell-scaffold microenvironment.