FURI | Summer 2022

Engineering Corynebacterium glutamicum with Malonate Pathway for Optimizing Flavonoid Production

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This project seeks to address the question: What is the effect of expressing a malonate pathway in C. glutamicum strains on naringenin output? It is hypothesized that overexpressing the MatB synthase and MatC protein transporter will cause an increase in malonyl-coA pools (a precursor for naringenin synthesis), ultimately increasing the naringenin output. Naringenin can be used as a supplement for farm animals, enabling them to produce healthier offspring and more nutritional products for human consumption at an accelerated rate to match the growing global demand for food.

Student researcher

Juhi Khandelwal

Chemical engineering

Hometown: Chandler, Arizona, United States

Graduation date: Spring 2025