FURI | Summer 2022

Engineering Corynebacterium glutamicum with Malonate Pathway for Optimizing Flavonoid Production

This project seeks to address the question: What is the effect of expressing a malonate pathway in C. glutamicum strains on naringenin output? It is hypothesized that overexpressing the MatB synthase and MatC protein transporter will cause an increase in malonyl-coA pools (a precursor for naringenin synthesis), ultimately increasing the naringenin output. Naringenin can be used as a supplement for farm animals, enabling them to produce healthier offspring and more nutritional products for human consumption at an accelerated rate to match the growing global demand for food.