FURI | Spring 2022

Engineering Corynebacterium glutamicum for the Production of Naringenin

In this work, the research team has engineered Corynebacterium glutamicum with the metabolic pathway for the production of naringenin, a natural anti-Alzheimer’s, an anti-bacterial, and anticancer medicine. The engineered strain overexpresses the heterologous proteins CHI, CHS, and 4CL that convert coumaryl-CoA and malonyl-CoA to naringenin. The team is also working on developing 3 more strains of C. glutamicum that have CHI, CHS, and 4CL from different sources.