FURI | Spring 2025

Effects of Calcium-binding Peptide Concentration and SBF Incubation Time on Electrospun Fiber Mineralization

Current methods for treating significant bone defects consist of autografts and allografts, which have many drawbacks. In recent years, interest has been rising in using tissue engineering scaffolds to create novel methods for directing cells to regenerate bone tissue. This project will use electrospinning to create nano- and microscale fibers as the basis for a tissue engineering scaffold. Mineralization can be induced by using a calcium-binding peptide and simulated body fluid. By understanding the effects of calcium-binding peptides and simulated body fluid on mineralization, new scaffolds can be created to direct stem cell differentiation and improve bone tissue healing.