FURI | Spring 2025

Developing and Testing a Clinically Translatable Method to Rapidly Assess and Monitor Local Cerebral Blood Flow Real-time Using EIS Measure by a Four-electrode System in the Motor Cortex of the Sprague-Dawley mice

Electrical impedance spectroscopy (EIS) offers a novel approach for real-time monitoring of local cerebral blood flow (CBF) changes, thus catering to existing limitations in neurostimulation feedback systems. This study aims to develop and validate an EIS-based method for detecting local CBF fluctuations in the motor cortex of Sprague-Dawley mice using a four-electrode configuration. By inducing controlled vascular changes with Endothelin-1 (ET-1), impedance variations will be correlated with regional cerebral blood flow changes. The findings thus obtained have the potential to integrate EIS into deep brain stimulation (DBS) systems, promising an improvement in electrode placement accuracy and optimization of stimulation parameters.