FURI | Spring 2025

Characterization of Diclofenac-Loaded Lipid Nanoparticles for Neutrophil Modulation

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Traumatic brain injury (TBI) results in acute and chronic neuroinflammation that can lead to long-term disability and even death. Nanoparticles (NPs) are a promising drug delivery system, given their physicochemical properties can be tuned to increase drug circulation time and bioavailability. In this study, drug-loaded lipid nanoparticles will be fabricated and incubated with immune cells to determine their anti-inflammatory effects. Diclofenac, an anti-inflammatory drug, will be utilized to decrease the expression of L-selectin on neutrophils. The results of this study will be used to inform future in vivo experiments focusing on decreasing the inflammatory response in the brain after injury.