FURI | Spring 2022

Assaying the Effect of Knock-Down of Ubiquitin-Specific Proteases in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare but aggressive cancer that resides in the pleural space surrounding the lungs. The median survival rate for MPM remains poor even with existing treatment procedures. Ubiquitination is one biological process known to influence protein and cell function. This research project examines cell proliferation and cell apoptosis in MPM by knock-down of ubiquitin-specific protease genes through lentiviral transduction. The shRNA molecules used for transduction have been designed and used in silencing the intended target gene. Upon completion, this research will provide newer methods of treatment for pleural mesothelioma.