Esther Sim
Biomedical engineering
Hometown: Scottsdale, Arizona
Graduation date: Spring 2020
GCSP research stipend | Spring 2019
Investigating the Role of SP5 in WNT Signaling Using an In-Vitro Model of Neural Patterning
This project attempts to better understand how the WNT transcriptional program is affected by β-catenin and SP5 by developing an in vitro model of neural patterning. This signaling pathway uses molecules that mediate cell to cell communication, which controls fundamental embryonic processes and regulates the formation of developmental markers. In the absence of WNT, the cytoplasmic β-catenin protein is constantly degraded by a destruction complex, which prevents β-catenin from reaching the nucleus, resulting in the repression of WNT target genes. Ultimately, by better understanding this signaling pathway, the mechanisms underlying WNT-related human defects can be understood better.
Mentor: David Brafman
It’s hip to be square.
Students presenting projects at the Fulton Forge Student Research Expo are encouraged to download this personal QR code and include it within your poster. This allows expo attendees to explore more about your project and about you in the future.
Right click the image to save it to your computer.